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Standards & Testing

49 articles

Quality Systems

Acceptance Sampling Plans for Medical Devices: AQL, Z1.4 & ISO 2859

How to build statistically valid medical device sampling plans under 21 CFR 820.250 / ISO 13485: AQL, ANSI/ASQ Z1.4, ISO 2859-1 switching rules, c=0 plans, and OC curves.

Quality Systems

Medical Device Reliability Testing: HALT, HASS, ALT & MTBF

A practical guide to medical device reliability testing: HALT vs HASS vs accelerated life testing, Weibull and MTBF, Arrhenius acceleration, and where it fits in ISO 13485 design V&V.

Regulatory

IVD Calibrator Traceability: ISO 17511, EU IVDR, and JCTLM Guide

Metrological traceability for IVD calibrators and control materials under ISO 17511:2020 and EU IVDR Annex I Section 9.3, covering calibration hierarchies, JCTLM resources, and common pitfalls.

Quality Systems

ISO 19011:2026: What the Updated Audit Standard Means for Medical Device Manufacturers

ISO 19011:2026 embeds hybrid auditing, digital evidence management, and updated auditor competence across the audit lifecycle — what ISO 13485 and QMSR programs need to update.

Biocompatibility

NAMs for Medical Device Biocompatibility: FDA, EU & ISO 10993 Guide (2026)

NAMs for medical device biocompatibility: FDA roadmap, EU phase-out plan, ISO 10993-5/-10/-23 in vitro alternatives, chemical characterization, and regulatory strategy.

Design Controls

Auto-Injector Critical-Task Matrix for Human Factors Validation

Guide to auto-injector critical-task matrices for human factors validation, including URRA inputs, dose confirmation, hold time, misfire recovery, training decay, and FDA evidence expectations.

510(k)

FDA ASCA Test Report Acceptance Package for 510(k) and De Novo

Step-by-step guide to ASCA evidence packages for 510(k) and De Novo submissions, including summary test reports, declarations, lab accreditation, scope matching, and FDA questions.

510(k)

FDA Third Party Review Program: 510(k) Due Diligence Checklist

Evaluate whether 3P510k review fits your device, with checks for product code eligibility, Accredited Person conflicts, eSTAR fit, timing, and risk.

Standards & Testing

IEC 62304 Edition 2: 2026 Software Lifecycle Changes for Devices

Prepare for IEC 62304 Edition 2 with process rigor levels, broader health software scope, AI/ML lifecycle provisions, cybersecurity integration, and compliance timelines.

Clinical Evidence

GCP for Medical Device Clinical Trials: ISO 14155 and ICH E6(R3) in 2026

Apply Good Clinical Practice to medical device trials under ISO 14155:2026 and ICH E6(R3), with sponsor duties, consent, safety reporting, and audit readiness.

Quality Systems

Cleaning Validation for Reusable Surgical Instruments: Soil, Residue, and Worst Case

Build cleaning validation protocols for reusable surgical instruments, covering test soils, residue endpoints, worst-case devices, ST98 criteria, sampling, and reports.

Regulatory

Digital Twins and Synthetic Data in Medical Device Validation

Practical guide to digital twins, synthetic data, and computational modeling in medical device submissions, covering FDA credibility guidance, ASME V&V 40, validation limits, and documentation.

IVD & Diagnostics

IVD Analytical Performance Validation: LoD, LoQ, Precision and Stability

Protocol-level guide to IVD analytical validation, covering LoD, LoQ, precision, interference, cross-reactivity, stability, CLSI methods, and FDA/IVDR evidence.

Standards & Testing

Nanotechnology in Medical Devices: Regulatory and Risk Assessment Guide

Assess medical devices with nanomaterials, including EU MDR Rule 19, FDA guidance, ISO 10993-22, exposure frameworks, nanotoxicology, sterilization, labeling, and regulatory strategy.

Regulatory

Pre-Filled Syringes and Auto-Injectors: Combination Product Regulatory Strategy

Regulatory strategy for pre-filled syringes and auto-injectors, covering FDA OCP/RFD, ISO 11608, human factors, EU MDR Article 117, QMSR, stability, and lifecycle changes.

Quality Systems

Supplier Audit Checklist for Medical Devices: ISO 13485, QMSR, and Critical Suppliers

Use this supplier audit checklist for ISO 13485 and FDA QMSR compliance, covering supplier risk, qualification, audit agendas, quality agreements, CAPA follow-up, and records.

Quality Systems

Washer-Disinfector Validation: ISO 15883, A0 and Routine Monitoring

Validate washer-disinfector equipment and cycles under ISO 15883, including IQ/OQ/PQ, A0 thermal disinfection, load configurations and routine monitoring.

Standards & Testing

ISO 17025 Test Laboratory Selection for Medical Devices: Complete Guide

Guide to selecting ISO 17025 accredited laboratories for medical device biocompatibility, EMC, safety, and sterilization testing, including FDA ASCA scope checks and cost factors.

Standards & Testing

ASTM D4169 Transportation Validation for Medical Device Packaging

Guide to ASTM D4169 packaging validation, including distribution cycles, assurance levels, drop, compression and vibration tests, ISO 11607 links, sample size, and acceptance criteria.

Risk Management

Fault Tree Analysis for Medical Device Risk Management: FTA vs FMEA

Guide to Fault Tree Analysis under ISO 14971, including FTA vs FMEA, AND/OR gates, probability calculations, examples, and when top-down risk analysis works best.