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MedDeviceGuide — IVD & Medical Device Knowledge Base

Risk Management

ISO 14971 Risk Management for Medical Devices: The Complete Guide

A comprehensive guide to implementing ISO 14971 risk management for medical devices — from hazard identification through risk control to post-production monitoring.

Regulatory

Japan PMDA Medical Device Approval: The Complete Guide

Navigate Japan's medical device approval system — PMDA pathways, QMS requirements, MAH structure, clinical trials, reimbursement, and practical market entry guidance.

Regulatory

Health Canada Medical Device License: The Complete Guide

How to obtain a Medical Device License from Health Canada — classification, MDSAP requirements, MDEL, application process, fees, and practical guidance for the Canadian market.

Quality Systems

ISO 13485 Certification — The Complete Guide for Medical Device Companies

Everything you need to know about ISO 13485 certification: requirements by clause, the certification process step-by-step, costs, timelines, how to choose a registrar, common audit findings, and how ISO 13485 fits with FDA QSR, EU MDR, and MDSAP.

Digital Health & AI

Software as a Medical Device (SaMD): The Complete Regulatory Guide

Everything you need to know about SaMD regulation — IMDRF classification, FDA pathways, EU MDR Rule 11, IEC 62304, IEC 82304-1, AI/ML frameworks, PCCP, Digital Health Center of Excellence, international SaMD frameworks (UK, Canada, Japan, Australia), cybersecurity, real product examples, and practical implementation guidance.

510(k)

The Complete Guide to FDA 510(k) Submissions

Everything you need to know about the FDA 510(k) process — from predicate device selection and substantial equivalence to eSTAR formatting, user fees, common deficiencies, and first-time submission tips.

Regulatory

Brazil ANVISA Medical Device Registration: The Complete Guide

How to register medical devices with ANVISA — classification, B-GMP via MDSAP, registration pathways, documentation, fees, and practical guidance for the Brazilian market.

Clinical Evidence

Clinical Evaluation Report (CER) for Medical Devices: The Complete Guide

How to write a Clinical Evaluation Report that meets EU MDR requirements and passes Notified Body review — methodology, structure, literature search strategy, and common pitfalls.

Quality Systems

MDSAP Audit: The Complete Guide to the Medical Device Single Audit Program

Everything about MDSAP — the single audit program covering FDA, Health Canada, TGA, ANVISA, and MHLW. Audit process, grading, preparation, costs, and how to pass.

Regulatory

FDA's QSR to QMSR Transition: What Medical Device Companies Need to Know

The FDA is aligning its Quality System Regulation with ISO 13485. Here's what the QMSR final rule means for your quality management system and what you need to do to prepare.

Regulatory

South Korea MFDS Medical Device Approval: The Complete Guide

Navigate South Korea's medical device regulatory system — MFDS classification, KGMP, approval pathways, clinical requirements, and practical market entry guidance.

Regulatory

Australia TGA Medical Device Registration: The Complete Guide

How to register medical devices with Australia's TGA — classification, ARTG inclusion, sponsor requirements, MDSAP, fees, and practical guidance for the Australian market.

EU MDR / IVDR

EU MDR and IVDR: The Complete Guide to European Medical Device Regulation

The definitive guide to EU MDR (2017/745) and IVDR (2017/746) — covering classification rules, conformity assessment, technical documentation, EUDAMED, UDI, transition timelines, and practical strategies for manufacturers navigating CE marking in 2026.

Biocompatibility

ISO 10993 Biocompatibility Testing for Medical Devices: The Complete Guide

A comprehensive guide to biological evaluation and biocompatibility testing under ISO 10993 — from categorization and test selection to chemical characterization and FDA expectations.

Regulatory

FDA Medical Device Classification: Product Codes, Device Classes, and Regulatory Pathways

How FDA classifies medical devices into Class I, II, and III — product codes, regulation numbers, how to determine your device's classification, and what it means for your regulatory pathway.

Regulatory

India CDSCO Medical Device Registration: The Complete Guide

How to register medical devices with India's CDSCO — MDR 2017 classification, import licensing, BIS requirements, clinical evidence, and practical market entry guidance.

Post-Market Surveillance

Post-Market Surveillance for Medical Devices: The Complete Guide

Everything you need to know about post-market surveillance (PMS) for medical devices — regulatory requirements under FDA and EU MDR/IVDR, PMS plan templates, PMCF studies, PSURs, vigilance reporting, and practical guidance for building a PMS system from scratch.

Design Controls

Design Verification vs. Design Validation for Medical Devices: What You Actually Need to Know

A comprehensive guide to design verification and design validation under FDA design controls and ISO 13485. Covers the V-model, verification methods, validation approaches, documentation, common 483 findings, and practical examples across device types.

Digital Health & AI

IEC 62304 Medical Device Software Lifecycle: The Complete Implementation Guide

How to implement IEC 62304 for medical device software development — safety classification, lifecycle processes, SOUP management, documentation requirements, and practical tips for agile teams.

Regulatory

UK Medical Device Regulation Post-Brexit: UKCA Marking, MHRA & The Complete Guide

Navigate UK medical device regulation after Brexit — MHRA framework, UKCA vs CE marking, UK Responsible Person, Northern Ireland Protocol, and practical compliance guidance.